(006) Methamphetamine-Induced Vaginal Lubrication

Abstract Introduction Vaginal dryness is a frequent complaint, especially in post-menopausal women. The physiology underlying the production of vaginal lubrication response to arousing stimuli established; however, no current pharmacological agents successfully target mechanisms within this physiology. Previous research from our lab has demonstrated that female methamphetamine (meth) users experience immediate excessive lubrication, accompanied by warmth or flushing sensation spreading chest areas pelvic region, when using drug intravenously (IV). physiological source previously undescribed effect meth could present potential mechanism enhance woman’s natural providing potentially life-changing option patients experiencing dryness. Objectives purpose study was determine if induced IV use reported previous occurs rats, and dose-dependent. This also sought begin uncover behind phenomenon. Methods Adult Wistar rats (n=8) were implanted with chronic indwelling jugular catheters allowed at least one week recover surgery. Rats anesthetized isoflurane gas infused seven doses ranging 0.015-0.96 mg/kg saline via catheter. Pre-weighed cotton-tipped swabs inserted into canal collected fluid secreted following administration. change weight swab taken as produced. Consequent studies examined several signaling molecules plasma known have an influence on including steroid hormones estradiol, progesterone testosterone, well gaseous vasodilator nitric oxide. These measured time points up 60 minutes after Results As hypothesized, increased dose-dependent manner. Doses 0.06 0.24 significant increases compared saline. Further, pre-meth levels, estradiol seen two 15 Significant progesterone, testosterone oxide ten Conclusions far-reaching implications since majority women will once, not recurrently. meth-induced elucidated, may provide treating only disorder, but millions suffering Disclosure No.